Gemfibrozil 1-O-β-Glucuronide
Gemfibrozil 1-O-β-Glucuronide
CAS: 91683-38-4
Molecular Formula: C21H30O9
Gemfibrozil 1-O-β-Glucuronide - Names and Identifiers
Gemfibrozil 1-O-β-Glucuronide - Physico-chemical Properties
| Molecular Formula | C21H30O9 |
| Molar Mass | 426.46 |
| Density | 1.32±0.1 g/cm3(Predicted) |
| Melting Point | >103°C (dec.) |
| Boling Point | 611.2±55.0 °C(Predicted) |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 2.68±0.70(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Stability | Very Hygroscopic |
| In vitro study | Gemfibrozil 1-O-β-Glucuronide significantly inhibits the OATP2 (OATP1B1)-mediated uptake of Cerivastatin (CER; HY-129458) with an IC 50 of 24.3 μM. Gemfibrozil 1-O-β-Glucuronide inhibits CYP2C8-mediated M1, M23 formation with IC 50 s of 5.38 μM, 4.30 μM, and has no effects for CYP2C8-mediated M3 formation. Gemfibrozil 1-O-β-Glucuronide has an IC 50 of 243 μM for the CYP3A4- mediated metabolism. |
Gemfibrozil 1-O-β-Glucuronide - Risk and Safety
| HS Code | 29389090 |
Gemfibrozil 1-O-β-Glucuronide - Reference Information
| biological activity | Gemfibrozil 1-o-β-glucuronate is a metabolite of Gemfibrozil (CI-719; HY-B0258), it is a potent and competitive P450 (CYP) subtype CYP2C8 inhibitor with an IC50 of 4.07 μm. |
Last Update：2024-04-09 20:15:17
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Product Name: Gemfibrozil 1-O-β-Glucuronide Visit Supplier Webpage Request for quotation
CAS: 91683-38-4
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 91683-38-4
Tel: 18301782025
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